Weight-loss Drugs Linked to Depression and Suicidal Thoughts: Study

A new study by South Korean researchers has found an association between the use of weight-loss medications and depression and suicidal thoughts among adults.

Researchers analysed mental health data from around 27,000 adults. Among them, 846 people reported using prescription weight-loss medications.

According to the study, people using weight-loss medications were 93% more likely to report depression compared with those who were not using the medicines.

The study also found that users were 168% more likely to report suicidal thoughts.

Weight regain and mental health

The researchers also reviewed data on people who had used GLP-1 medications over a period of nearly 10 years.

The findings suggested that mental health risks were more strongly associated with people who regained weight after using the medication.

Researchers said weight regain after treatment may be linked with a higher risk of depression and suicidal thoughts.

However, the study only found an association and does not prove that weight-loss medications directly cause depression or suicidal thoughts.

Previous safety concerns

Possible links between weight-loss medications and suicidal thoughts have also been examined in previous safety reviews.

The US Food and Drug Administration (FDA) received reports from some patients who said they experienced suicidal thoughts or severe feelings of hopelessness while taking such medications.

Some patients also reported having no previous history of mental health problems before starting the medicines.

Researchers said further studies are needed to better understand the possible mental health effects of medications used for weight loss and obesity treatment.